Antifungal therapy and surgical drainage for the treatment of a cerebral abscess caused by in a Scedosporium apiospermum renal transplant patient - a case report

the asexual form of , is a Scedosporium apiospermum, Pseudallescheria boydii filamentous, opportunistic fungus which can be found in environmental sources all over the world. It is a human pathogen mostly associated with lung, bone and joint infections and less frequently with infections of the central nervous system (CNS). The latter is generally related to the patient’s immune state, and occurs most frequently in immunocompromised patients. We present the case of a 64-year-old male patient with a background of chronic kidney failure secondary to nephroangiosclerosis and a renal transplantation who presented with left-sided hemiplegia and dysarthria. A brain MRI revealed a hyperintense lesion with ring enhancement at the right paramedian posterior frontal subcortical area with an associated vasogenic edema. A stereotactic biopsy of the lesion revealed the presence of . The patient received a S. apiospermum combined therapy of voriconazole and terbinafine with surgical drainage, which led to temporarily clinical and radiological improvement. Juan Pablo Caeiro ( ) Corresponding author: [email protected] Garzón MI, Abiega C, Zarate AH How to cite this article: et al. Antifungal therapy and surgical drainage for the treatment of a cerebral abscess caused by in a renal transplant patient a case report [version 1; referees: 1 approved, 1 Scedosporium apiospermum 2014, :70 (doi: ) approved with reservations] F1000Research 3 10.12688/f1000research.3535.1 © 2014 Garzón MI . This is an open access article distributed under the terms of the , which Copyright: et al Creative Commons Attribution Licence permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Data associated with the article are available under the terms of the (CC0 1.0 Public domain dedication). Creative Commons Zero "No rights reserved" data waiver The author(s) declared that no grants were involved in supporting this work. Grant information: Competing interests: No competing interests were disclosed. 13 Mar 2014, :70 (doi: ) First published: 3 10.12688/f1000research.3535.1 Referee Status: